Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 5/20 | 0.46 |
| ▸ | THRA | P10827 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821784 | 0.91 | ALDH1A1 (0.52) | ALDH1A1KMT2AMAPTKDM4EMEN1 | |
| SCHEMBL2828409 | 0.87 | PLA2G2A (0.47) | TDP1ESR1PLA2G2A | |
| SCHEMBL8442192 | 0.86 | ALDH1A1 (0.48) | ALDH1A1KMT2AMAPTKDM4ETHRB | |
| SCHEMBL2825313 | 0.81 | LMNA (0.44) | ALDH1A1MAPTKDM4ETDP1LMNA | |
| SCHEMBL2826636 | 0.81 | CA12 (0.47) | KMT2AMEN1CYP1A2TDP1LMNA | |
| SCHEMBL22868140 | 0.81 | L3MBTL1 (0.48) | KMT2AMEN1CYP1A2TDP1LMNA | |
| SCHEMBL288382 | 0.80 | BRD4 (0.53) | ALDH1A1KMT2AMAPTMEN1CYP1A2 | |
| SCHEMBL2822392 | 0.80 | CA12 (0.46) | KMT2AMAPTMEN1CYP1A2TDP1 | |
| SCHEMBL2828373 | 0.79 | THRB (0.42) | ALDH1A1KMT2AMAPTKDM4ETHRB | |
| SCHEMBL30938045 | 0.79 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |