Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9112308 | 0.95 | PLAU (0.43) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL731893 | 0.89 | PLAU (0.47) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL3248709 | 0.89 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL3250398 | 0.89 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL29986248 | 0.89 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL18154032 | 0.87 | PLAU (0.48) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL31122674 | 0.87 | PLAU (0.48) | PLAUCYP2A6F12NCF1NOS3 | |
| Hydrochloric Acid SCHEMBL11152119 | 0.85 | PLAU (0.47) | PLAUCYP2A6F12NCF1NOS3 | |
| Bromide SCHEMBL18154039 | 0.85 | PLAU (0.47) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL4067893 | 0.82 | CYP2A6 (0.48) | PLAUCYP2A6F12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230254-B1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) | 2021-09-22 | — | — | EP | disclosed |
| US-11072606-B2 | Compositions and methods for treating diseases and conditions | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-07-27 | — | — | US | disclosed |
| US-20200396995-A1 | INHIBITORS OF GRB2-ASSOCIATED BINDING PROTEIN 1 (GAB1) AND METHODS OF TREATING CANCER USING THE SAME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2020-12-24 | — | — | US | disclosed |
| CN-107207407-B | Compositions and methods for treating diseases and disorders | 高等教育联邦系统-匹兹堡大学 | 2020-12-01 | — | — | CN | disclosed |
| US-20200087294-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-03-19 | — | — | US | disclosed |
| US-10487076-B2 | Compositions and methods for treating diseases and conditions | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-11-26 | — | — | US | disclosed |
| US-10448637-B2 | Inhibitors of GRB2-associated binding protein 1 (GAB1) and methods of treating cancer using the same | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-10-22 | — | — | US | disclosed |
| US-10092526-B2 | Compositions and methods for treating respiratory injury or disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2018-10-09 | — | — | US | disclosed |
| US-20180134693-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180071232-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-03-15 | — | — | US | disclosed |
| US-20040152696-A1 | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers | EURO-CELTIQUE S.A. | 2004-08-05 | — | — | US | disclosed |
| US-20040127433-A1 | excellent antibacterial activity especially against a typical acid-fast mycobacteria including multiple drug-resistant bacteria | HOKURIKU SEIYAKU CO., LTD. (JP) | 2004-07-01 | — | — | US | disclosed |
| US-20040116415-A1 | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers | EURO-CELTIQUE S.A. | 2004-06-17 | — | — | US | disclosed |
| US-20040054162-A1 | Molecular detection systems utilizing reiterative oligonucleotide synthesis | RIBOMED BIOTECHNOLOGIES, INC. | 2004-03-18 | — | — | US | disclosed |
| WO-2003095625-A2 | METHOD FOR CYTOPROTECTION THROUGH MDM2 AND HDM2 INHIBITION | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |
| EP-1323726-A1 | ERYTHROMYCIN DERIVATIVES AND MEDICINES CONTAINING THE SAME | HOKURIKU SEIYAKU CO., LTD. (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-20030109518-A1 | Substituted 1,4-benzodiazepines and uses thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-06-12 | — | — | US | disclosed |
| US-20030105111-A1 | Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-06-05 | — | — | US | disclosed |
| WO-2002043680-A1 | FIXATION OF CARBOHYDRATES TO FIBROUS MATERIALS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2002-06-06 | — | — | WO | disclosed |
| WO-2002043678-A2 | ENZYMATIC FIXATION OF DERIVATISED CARBOHYDRATES TO FIBROUS MATERIALS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072606-B2 | Compositions and methods for treating diseases and conditions | C1S, SLC10A1, C1R | PLAU 2370/4885CYP2A6 39/4885F12 27/4885 |
| US-10487076-B2 | Compositions and methods for treating diseases and conditions | C1S, SLC10A1, C1R | PLAU 2442/4885CYP2A6 35/4885F12 32/4885 |
| US-20040127433-A1 | excellent antibacterial activity especially against a typical acid-fast mycobacteria including multiple drug-resistant bacteria | MAPRE1, MAPRE2, MRPS27 | PLAU 4592/4885CYP2A6 1920/4885F12 4585/4885 |
| US-20040152696-A1 | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers | CACNA1C, CACNA1D, SCN2B | PLAU 3458/4885CYP2A6 3060/4885F12 2590/4885 |
| US-20180071232-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C9, C1S | PLAU 1286/4885CYP2A6 177/4885F12 15/4885 |
| US-20200396995-A1 | INHIBITORS OF GRB2-ASSOCIATED BINDING PROTEIN 1 (GAB1) AND METHODS OF TREATING CANCER USING THE SAME | GAB1, GRB2, BCR | PLAU 3607/4885CYP2A6 4510/4885F12 4254/4885 |
| US-10092526-B2 | Compositions and methods for treating respiratory injury or disease | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C9, C1S | PLAU 1286/4885CYP2A6 177/4885F12 15/4885 |
| US-20040054162-A1 | Molecular detection systems utilizing reiterative oligonucleotide synthesis | POLRMT, RNGTT, POLI | PLAU 2950/4885CYP2A6 2571/4885F12 4778/4885 |
| US-20030105111-A1 | Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes | DHFR, FPR1, CYP1A1 | PLAU 4623/4885CYP2A6 316/4885F12 654/4885 |
| US-20200087294-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | C1S, SLC10A1, C1R | PLAU 2370/4885CYP2A6 39/4885F12 27/4885 |
| US-10448637-B2 | Inhibitors of GRB2-associated binding protein 1 (GAB1) and methods of treating cancer using the same | GAB1, GRB2, BCR | PLAU 3691/4885CYP2A6 4496/4885F12 3984/4885 |
| US-20180134693-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | C1S, SLC10A1, C1R | PLAU 2442/4885CYP2A6 35/4885F12 32/4885 |
| US-20030109518-A1 | Substituted 1,4-benzodiazepines and uses thereof | MDM2, CBR1, ADRM1 | PLAU 4699/4885CYP2A6 229/4885F12 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.