SCHEMBL28280786

SCHEMBL28280786

FC(F)=C(F)Oc1ccc(-c2ccc(Br)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.39
ALDH1A1 P00352 1/20 0.39
MAPT P10636 2/20 0.34
LDHA P00338 1/20 0.34
KIF11 P52732 1/20 0.34
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
TP53 P04637 1/20 0.33
CYP2A6 P11509 1/20 0.33
MCL1 Q07820 2/20 0.33
MGLL Q99685 1/20 0.33
LTA4H P09960 1/20 0.33
CA2 P00918 2/20 0.32
CA9 Q16790 2/20 0.32
APP P05067 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1505790 0.94 CYP2A6 (0.38) MAPK1ALDH1A1MAPTLDHAMEN1
SCHEMBL1471830 0.91 MAPT (0.37) MAPK1ALDH1A1MAPTLDHAMEN1
SCHEMBL11956152 0.89 ALDH1A1 (0.32) MAPK1ALDH1A1TP53MGLL
SCHEMBL1505815 0.89 KIF11 (0.39) MAPK1KIF11MEN1LMNARAB9A
SCHEMBL8934991 0.89 KIF11 (0.39) MAPK1KIF11MEN1LMNARAB9A
SCHEMBL12833375 0.89 KIF11 (0.39) MAPK1KIF11MEN1LMNARAB9A
SCHEMBL1505863 0.83 ESR1 (0.39) MAPK1MAPTKIF11MEN1LMNA
SCHEMBL4530562 0.82 RAB9A (0.35) ALDH1A1MAPTKIF11MEN1LMNA
SCHEMBL13422323 0.81 ESR2 (0.50) MAPK1KIF11MEN1RAB9AKMT2A
SCHEMBL13422208 0.81 KMT2A (0.43) ALDH1A1MAPTKIF11MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109516923-A Compounds and organic luminescent device comprising it 东进世美肯株式会社 2019-03-26 CN disclosed