SCHEMBL28282917

SCHEMBL28282917

[Li]c1cccc(N2CCCCC2)c1C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.50
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
LMNA P02545 1/20 0.47
KEAP1 Q14145 1/20 0.46
ADRB1 P08588 1/20 0.44
MAPK1 P28482 3/20 0.44
NCF1 P14598 1/20 0.42
ALDH1A3 P47895 2/20 0.41
ALDH1A1 P00352 5/20 0.40
MAPT P10636 4/20 0.40
NPSR1 Q6W5P4 3/20 0.40
TSHR P16473 2/20 0.40
L3MBTL1 Q9Y468 4/20 0.40
NPC1 O15118 1/20 0.40
KDM4E B2RXH2 1/20 0.39
EGFR P00533 1/20 0.39
RAF1 P04049 1/20 0.39
ALOX12 P18054 1/20 0.39
MAP2K1 Q02750 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9064919 0.82 GAA (0.43) GAAMEN1KMT2ALMNAKEAP1
SCHEMBL9063707 0.82 GAA (0.43) GAAMEN1KMT2ALMNAKEAP1
SCHEMBL3729970 0.81 KEAP1 (0.59) GAAKEAP1MAPK1NCF1ALDH1A1
SCHEMBL3725948 0.81 KEAP1 (0.59) GAAKEAP1MAPK1NCF1ALDH1A1
SCHEMBL8894088 0.80 LMNA (0.68) GAAMEN1KMT2ALMNAADRB1
SCHEMBL9065302 0.80 ALDH1A1 (0.43) GAAMEN1KMT2ALMNAKEAP1
SCHEMBL9065218 0.80 LMNA (0.68) GAAMEN1KMT2ALMNAADRB1
SCHEMBL30228454 0.80 LMNA (0.68) GAAMEN1KMT2ALMNAADRB1
SCHEMBL3727593 0.79 KEAP1 (0.56) GAAKMT2AKEAP1ADRB1MAPK1
SCHEMBL23843550 0.78 ADRB1 (0.69) GAAMEN1KMT2ALMNAADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109384982-A Modified conjugated diene polymer composition and tire 旭化成株式会社 2019-02-26 CN disclosed