Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PER2 | O15055 | 15/20 | 0.45 |
| ▸ | CRY2 | Q49AN0 | 13/20 | 0.41 |
| ▸ | CRY1 | Q16526 | 8/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28228399 | 0.79 | MAPT (0.47) | — | |
| SCHEMBL28229124 | 0.79 | RORA (0.47) | KDM4EALDH1A1 | |
| SCHEMBL8143242 | 0.76 | MAPT (0.52) | KDM4EALDH1A1PER2CRY2CRY1 | |
| SCHEMBL17955862 | 0.74 | PTGER4 (0.49) | KDM4EALDH1A1PER2CRY2CRY1 | |
| SCHEMBL16156855 | 0.74 | FABP4 (0.59) | KDM4EALDH1A1PER2CRY2 | |
| SCHEMBL16098656 | 0.73 | FABP4 (0.53) | KDM4E | |
| SCHEMBL8148630 | 0.73 | MAPT (0.54) | KDM4EALDH1A1PER2CRY2CRY1 | |
| SCHEMBL31609292 | 0.71 | PER2 (0.48) | ALDH1A1PER2CRY2CRY1 | |
| SCHEMBL29623057 | 0.71 | PER2 (0.51) | ALDH1A1PER2 | |
| SCHEMBL29165319 | 0.71 | PER2 (0.42) | KDM4EALDH1A1PER2CRY2CRY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285793-B | Fluorine-substituted bimolecular carbazole derivative, and preparation method and application thereof | 广州中医药大学(广州中医药研究院) | 2022-04-22 | — | — | CN | disclosed |
| CN-111285793-A | Fluorine-substituted bimolecular carbazole derivative, and preparation method and application thereof | 广州中医药大学(广州中医药研究院) | 2020-06-16 | — | — | CN | disclosed |
| CN-110003172-A | The amides containing carbazole, carbamates and ureas as cryptochrome regulator | 同步制药公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-106458891-B | Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators | 同步制药公司 | 2019-04-09 | — | — | CN | disclosed |