Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.37 |
| ▸ | PGR | P06401 | 5/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.37 |
| ▸ | AR | P10275 | 5/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27369292 | 0.78 | GPR84 (0.44) | NR3C1NR3C2HTR2AKDM4EALDH1A1 | |
| SCHEMBL27965809 | 0.77 | CYP2A6 (0.35) | JAK2HTR2A | |
| SCHEMBL27906752 | 0.77 | FFAR1 (0.43) | HTR2A | |
| SCHEMBL27524231 | 0.77 | NR4A2 (0.46) | NR3C1PGRNR3C2HTR2A | |
| SCHEMBL27771264 | 0.77 | HTR2A (0.44) | L3MBTL1HTR2AKDM4EALDH1A1 | |
| SCHEMBL28678155 | 0.76 | HTR2A (0.45) | HTR2A | |
| SCHEMBL27908791 | 0.74 | HTR2A (0.35) | HTR2AKDM4EALDH1A1 | |
| SCHEMBL28880740 | 0.74 | PTGS2 (0.43) | JAK2 | |
| SCHEMBL28818816 | 0.73 | SLC6A4 (0.39) | NR3C2HTR2AALDH1A1 | |
| SCHEMBL28291599 | 0.73 | POLB (0.37) | L3MBTL1SLC6A2HTR2AHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748840-A | A kind of synthetic method of 2- substituted indole derivative | 中国医学科学院药物研究所 | 2019-05-14 | — | — | CN | disclosed |