SCHEMBL28294619

SCHEMBL28294619

CC(=S)Nc1ccc(I)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS2R38 P59533 1/20 0.60
IDO1 P14902 1/20 0.57
SIGMAR1 Q99720 1/20 0.44
GPR174 Q9BXC1 1/20 0.41
ALDH1A1 P00352 4/20 0.41
GAA P10253 3/20 0.41
MAPT P10636 3/20 0.41
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
QPCT Q16769 1/20 0.40
FPR2 P25090 1/20 0.40
KDM4E B2RXH2 1/20 0.39
THRB P10828 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
TRPV1 Q8NER1 1/20 0.39
CYP3A4 P08684 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14511451 0.87 TAS2R38 (0.75) TAS2R38ALDH1A1GAAMAPTKMT2A
SCHEMBL21985779 0.81 TAS2R38 (0.60) TAS2R38IDO1ALDH1A1GAAMAPT
SCHEMBL5518697 0.81 IDO1 (0.63) TAS2R38IDO1SIGMAR1ALDH1A1GAA
SCHEMBL14872243 0.78 TAS2R38 (0.62) TAS2R38ALDH1A1GAAMAPTKMT2A
SCHEMBL863133 0.78 TAS2R38 (0.62) TAS2R38ALDH1A1GAAMAPTKMT2A
SCHEMBL23752222 0.78 IDO1 (0.59) TAS2R38IDO1SIGMAR1GPR174ALDH1A1
SCHEMBL8705118 0.78 GAA (0.65) TAS2R38IDO1ALDH1A1GAAMAPT
SCHEMBL13201378 0.77 IDO1 (0.64) IDO1GPR174ALDH1A1GAAMAPT
SCHEMBL11718858 0.76 SMN1; SMN2 (0.67) TAS2R38ALDH1A1GAAMAPTKMT2A
SCHEMBL11738124 0.76 MEN1 (0.62) TAS2R38IDO1ALDH1A1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114956933-A Marker containing isotope oxygen atom and preparation method and application thereof 清华大学 2022-08-30 CN disclosed
CN-109796387-A The preparation method of thio trifluoroacetyl amine compounds 温州大学 2019-05-24 CN disclosed