SCHEMBL28298652

SCHEMBL28298652

O=[SH](=O)c1ccc(F)c(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 5/20 0.37
KCNE1 P15382 1/20 0.33
KCNQ1 P51787 1/20 0.33
TTR P02766 1/20 0.31
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6426040 0.73 KCNN4 (0.40) KCNN4KCNE1KCNQ1ALDH1A1
SCHEMBL28109693 0.70 CA1 (0.46)
Hydrogen Sulfide SCHEMBL28109666 0.69 KCNN4 (0.50) KCNN4KCNE1KCNQ1ALDH1A1TSHR
SCHEMBL14043336 0.68 CES2 (0.41)
SCHEMBL29046702 0.67 CES2 (0.41) ALDH1A1TSHR
SCHEMBL21518215 0.64 KIF11 (0.44)
SCHEMBL25629806 0.64 GPR3 (0.40) TTRALDH1A1TSHR
SCHEMBL16908303 0.63 ALDH1A1 (0.34) ALDH1A1
SCHEMBL14545989 0.63 ACHE (0.37) TSHR
SCHEMBL13305428 0.63 CA3 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109851535-A A method of preparing 4- fluoro- 3- (trifyl) benzsulfamide 天津现代职业技术学院 2019-06-07 CN disclosed