Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826533 | 0.89 | ALDH1A1 (0.39) | RAB9ANPC1GRM5ALDH1A1MAPT | |
| SCHEMBL2825994 | 0.88 | CHRNB2 (0.40) | FAAHRAB9ANPC1GRM5TP53 | |
| SCHEMBL2831443 | 0.84 | RAB9A (0.49) | RAB9ANPC1GRM5ALDH1A1POLB | |
| SCHEMBL2830218 | 0.84 | GBA1 (0.46) | RAB9ANPC1GRM5ALDH1A1POLB | |
| SCHEMBL2831279 | 0.81 | RAB9A (0.41) | RAB9ANPC1GRM5ALDH1A1MAPT | |
| SCHEMBL2827571 | 0.80 | LMNA (0.47) | FAAHRAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL2830797 | 0.80 | RAB9A (0.51) | RAB9ANPC1GRM5MAPTTP53 | |
| SCHEMBL2831394 | 0.80 | RAB9A (0.43) | RAB9ANPC1GRM5ALDH1A1POLB | |
| SCHEMBL2825977 | 0.79 | GRM5 (0.50) | RAB9ANPC1GRM5MAPTTP53 | |
| SCHEMBL2830006 | 0.78 | RAB9A (0.44) | RAB9ANPC1GRM5ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |