SCHEMBL2835555

SCHEMBL2835555

Cc1nc(-c2cc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)ccc2Cl)sc1C

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.33
MDM2 Q00987 1/20 0.31
AGPAT2 O15120 1/20 0.31
PIK3R2 O00459 1/20 0.31
RXFP1 Q9HBX9 1/20 0.30
PTGS2 P35354 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1573358 0.85 KMT2A (0.34) MAPTAGPAT2
SCHEMBL1573450 0.84 ALDH1A1 (0.41) MAPT
SCHEMBL2835569 0.83 THRB (0.41) MAPTAGPAT2RXFP1
SCHEMBL2838060 0.82 F2RL3 (0.38) MAPTRXFP1
SCHEMBL5732815 0.81 CNR1 (0.33) MAPT
SCHEMBL2841129 0.80 KDM4E (0.35) MAPTPIK3R2
SCHEMBL2834141 0.80 GAA (0.31)
SCHEMBL2832383 0.80 BCAT1 (0.43) MDM2
SCHEMBL2836889 0.79 GABRA1 (0.37) MAPT
SCHEMBL2836064 0.79 MAPT (0.43) MAPTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US claimed
US-7754880-B2 Uracils having a herbicidal activity ISAGRO RICERCA S.R.L. (IT) 2010-07-13 US disclosed
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060025591-A1 New uracils having a herbicidal activity UNG, DDT, UMPS MAPT 3499/4885MDM2 183/4885AGPAT2 2018/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.