SCHEMBL2836064

SCHEMBL2836064

Cn1c(C(F)(F)F)cc(=O)n(-c2ccc(Cl)c(-c3nc(-c4ccc(Cl)cc4)cs3)c2)c1=O

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.43
IDH1 O75874 4/20 0.41
TP53 P04637 3/20 0.41
THRB P10828 1/20 0.41
LDHA P00338 1/20 0.40
CYP19A1 P11511 1/20 0.38
EIF4E P06730 3/20 0.38
KDM4E B2RXH2 2/20 0.37
RAB9A P51151 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
LMNA P02545 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2836889 0.84 GABRA1 (0.37) MAPTKDM4E
SCHEMBL5732815 0.83 CNR1 (0.33) MAPTSMN1; SMN2
SCHEMBL2838729 0.80 KDM4E (0.39) EIF4EKDM4ESMN1; SMN2LMNA
SCHEMBL6205890 0.80 EIF4E (0.30) EIF4E
SCHEMBL2836314 0.80 MAOA (0.41) MAPTLDHAKDM4ESMN1; SMN2
SCHEMBL2841129 0.79 KDM4E (0.35) MAPTKDM4ERAB9AMEN1NPC1
SCHEMBL2835555 0.79 MAPT (0.33) MAPTRXFP1
SCHEMBL2835569 0.78 THRB (0.41) MAPTTHRBKDM4ERAB9ASMN1; SMN2
SCHEMBL2835936 0.78 GAA (0.46) MAPTTP53CYP19A1RAB9ALMNA
SCHEMBL8993528 0.77 SMN1; SMN2 (0.44) MAPTKDM4ESMN1; SMN2LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US claimed
US-7754880-B2 Uracils having a herbicidal activity ISAGRO RICERCA S.R.L. (IT) 2010-07-13 US disclosed
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060025591-A1 New uracils having a herbicidal activity UNG, DDT, UMPS MAPT 3499/4885IDH1 199/4885TP53 398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.