SCHEMBL2841129

SCHEMBL2841129

Cn1c(C(F)(F)F)cc(=O)n(-c2ccc(Cl)c(-c3nccs3)c2)c1=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA3 P34903 1/20 0.32
GABRA2 P47869 1/20 0.32
PIK3R2 O00459 1/20 0.32
MAT2A P31153 1/20 0.31
S1PR1 P21453 1/20 0.30
TUBB4A P04350 1/20 0.30
TUBB P07437 1/20 0.30
TUBA3C P0DPH7 1/20 0.30
TUBA1B P68363 1/20 0.30
TUBA4A P68366 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5732815 0.82 CNR1 (0.33) ALDH1A1MAPT
SCHEMBL2835555 0.80 MAPT (0.33) MAPTPIK3R2
SCHEMBL2836889 0.80 GABRA1 (0.37) KDM4EALDH1A1MAPTGABRA1GABRG2
SCHEMBL2836064 0.79 MAPT (0.43) KDM4EMEN1NPC1MAPTRAB9A
SCHEMBL6771155 0.79 ADORA1 (0.31)
SCHEMBL2834141 0.79 GAA (0.31) GAA
SCHEMBL2835569 0.78 THRB (0.41) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL6205890 0.78 EIF4E (0.30)
SCHEMBL2838729 0.78 KDM4E (0.39) KDM4EALDH1A1GAA
SCHEMBL2836314 0.78 MAOA (0.41) KDM4EALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US claimed
US-7754880-B2 Uracils having a herbicidal activity ISAGRO RICERCA S.R.L. (IT) 2010-07-13 US disclosed
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060025591-A1 New uracils having a herbicidal activity UNG, DDT, UMPS KDM4E 1747/4885MEN1 4609/4885NPC1 4643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.