Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28360338 | 0.81 | MCL1 (0.46) | SLC9A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL28364015 | 0.81 | CNR2 (0.31) | KMT2AMEN1 | |
| SCHEMBL28586394 | 0.77 | KMO (0.34) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL28360382 | 0.77 | LMNA (0.43) | KMT2AMEN1MAPTKDM4ELMNA | |
| SCHEMBL28364142 | 0.73 | RXFP1 (0.43) | KMT2AMEN1 | |
| SCHEMBL28360376 | 0.73 | MCL1 (0.49) | HPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28453540 | 0.70 | ESR1 (0.39) | HPGDKMT2AMEN1NPC1RAB9A | |
| SCHEMBL7877970 | 0.69 | SLC9A1 (0.59) | SLC9A1PABPC1EIF4HHPGDMAPT | |
| SCHEMBL5837445 | 0.68 | KMT2A (0.47) | HPGDKMT2AMEN1MAPTTSHR | |
| SCHEMBL2276306 | 0.67 | SLC9A1 (0.64) | SLC9A1HPGDMAPTALKBH5FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110669046-B | Polysubstituted tetrahydro-gamma-carboline derivative with multiple chiral centers and preparation method of stereo diversity of polysubstituted tetrahydro-gamma-carboline derivative | 武汉大学 | 2021-07-06 | — | — | CN | disclosed |
| CN-110669046-A | Polysubstituted tetrahydro-gamma-carboline derivative with multiple chiral centers and preparation method of stereo diversity of polysubstituted tetrahydro-gamma-carboline derivative | 武汉大学 | 2020-01-10 | — | — | CN | disclosed |