Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 4/20 | 0.39 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.39 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.35 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.33 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3747429 | 0.88 | TTR (0.38) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2862747 | 0.82 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL3809665 | 0.82 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2863234 | 0.76 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL3807368 | 0.76 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2867512 | 0.76 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2867768 | 0.76 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL21522353 | 0.76 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2864157 | 0.76 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2861103 | 0.76 | CA1 (0.48) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116744978-A | anti-HER 2 immunoconjugates and uses thereof | 博尔特生物治疗药物有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-111087523-B | Normal-temperature curing fluorocarbon resin emulsion for back plate film and preparation method and application thereof | 山东华夏神舟新材料有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-111087523-A | Normal-temperature curing fluorocarbon resin emulsion for back plate film and preparation method and application thereof | 山东华夏神舟新材料有限公司 | 2020-05-01 | — | — | CN | disclosed |