SCHEMBL2839765

SCHEMBL2839765

C[Si](C)(C)OC(c1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.41
SCN1A P35498 3/20 0.41
SCN2A Q99250 3/20 0.41
SCN3A Q9NY46 3/20 0.41
CHRM2 P08172 3/20 0.41
ADRA2A P08913 3/20 0.41
CHRM1 P11229 3/20 0.41
SLC6A2 P23975 3/20 0.41
ADRA1A P35348 3/20 0.41
OPRM1 P35372 3/20 0.41
DRD3 P35462 3/20 0.41
SLC6A3 Q01959 3/20 0.41
KCNH2 Q12809 3/20 0.41
LMNA P02545 2/20 0.41
CYP2D6 P10635 2/20 0.41
CHRM4 P08173 2/20 0.41
CHRM5 P08912 2/20 0.41
ADRA2B P18089 2/20 0.41
CHRM3 P20309 2/20 0.41
HRH2 P25021 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2843916 0.87 PTGS2 (0.42) SMN1; SMN2
SCHEMBL7716632 0.85 HTT (0.41) HTTSCN1ASCN2ASCN3ACHRM2
SCHEMBL8851108 0.83 IDO1 (0.60) CHRM2ADRA2ACHRM1SLC6A2OPRM1
SCHEMBL15803228 0.82 IDO1 (0.38) HTTSCN1ASCN2ASCN3ACHRM2
SCHEMBL1417280 0.82 THRB (0.39) HTTADRA2ASLC6A2SLC6A3LMNA
SCHEMBL6282856 0.82 THRB (0.39) HTTADRA2ASLC6A2SLC6A3LMNA
SCHEMBL2839726 0.82 FAAH (0.43) SMN1; SMN2IDO1TDO2
SCHEMBL7718706 0.79 IDO1 (0.42) HTTSCN1ASCN2ASCN3ACHRM2
SCHEMBL2840462 0.79 FAAH (0.35) CYP2D6CYP1A2TSHRSMN1; SMN2
SCHEMBL1065153 0.79 IDO1 (0.40) HTTSCN1ASCN2ASCN3ACHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3044227-B1 USE OF CYCLOHEXA-2,5-DIEN-1-YL-SILANES AS PRECURSORS FOR GASEOUS HYDROSILANES UNIV BERLIN TECH (DE) 2017-11-08 EP disclosed
US-9518070-B2 Use of cyclohexa-2,5-dien-1-yl-silanes as precursors for gaseous hydrosilanes TECHNISCHE UNIVERSITAET BERLIN (DE) 2016-12-13 US disclosed
US-9518070-B2 Use of cyclohexa-2,5-dien-1-yl-silanes as precursors for gaseous hydrosilanes TECHNISCHE UNIVERSITAET BERLIN (DE) 2016-12-13 US disclosed
US-9518070-B2 Use of cyclohexa-2,5-dien-1-yl-silanes as precursors for gaseous hydrosilanes TECHNISCHE UNIVERSITAET BERLIN (DE) 2016-12-13 US disclosed
US-20160222037-A1 USE OF CYCLOHEXA-2,5-DIEN-1-YL-SILANES AS PRECURSORS FOR GASEOUS HYDROSILANES TECHNISCHE UNIVERSITAET BERLIN (DE) 2016-08-04 US disclosed
US-20160222037-A1 USE OF CYCLOHEXA-2,5-DIEN-1-YL-SILANES AS PRECURSORS FOR GASEOUS HYDROSILANES TECHNISCHE UNIVERSITAET BERLIN (DE) 2016-08-04 US disclosed
US-20160222037-A1 USE OF CYCLOHEXA-2,5-DIEN-1-YL-SILANES AS PRECURSORS FOR GASEOUS HYDROSILANES TECHNISCHE UNIVERSITAET BERLIN (DE) 2016-08-04 US disclosed
EP-3044227-A1 USE OF CYCLOHEXA-2,5-DIEN-1-YL-SILANES AS PRECURSORS FOR GASEOUS HYDROSILANES Technische Universität Berlin (DE) 2016-07-20 EP disclosed
EP-2438989-B1 USE OF ASYMMETRIC HYDROGENATION CATALYST TAKASAGO PERFUMERY CO LTD (JP) 2016-04-13 EP disclosed
US-9061959-B2 Method for manufacturing optically active menthol TAKASAGO INTERNATIONAL CORPORATION (JP) 2015-06-23 US disclosed
EP-2647616-A1 METHOD FOR MANUFACTURING OPTICALLY ACTIVE MENTHOL Takasago International Corporation (JP) 2013-10-09 EP disclosed
EP-2646150-A1 CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBONYL COMPOUND USING THE SAME Takasago International Corporation (JP) 2013-10-09 EP disclosed
US-20130253228-A1 METHOD FOR MANUFACTURING OPTICALLY ACTIVE MENTHOL TAKASAGO INTERNATIONAL CORPORATION (JP) 2013-09-26 US disclosed
US-20130217895-A1 CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBONYL COMPOUND USING THE SAME TAKASAGO INTERNATIONAL CORPORATION (JP) 2013-08-22 US disclosed
EP-2543437-A2 HOMOGENEOUS ASYMMETRIC HYDROGENATION CATALYST Takasago International Corporation (JP) 2013-01-09 EP disclosed
US-8217204-B2 Catalyst for asymmetric hydrogenation TAKASAGO INTERNATIONAL CORPORATION (JP) 2012-07-10 US disclosed
WO-2012074128-A1 CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBONYL COMPOUND USING THE SAME TAKASAGO INTERNATIONAL CORPORATION (JP) 2012-06-07 WO disclosed
US-20120136176-A1 CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBONYL COMPOUND USING THE SAME TAKASAGO INTERNATIONAL CORPORATION (JP) 2012-05-31 US disclosed
EP-2457655-A2 Catalyst for asymmetric hydrogenation comprising peptides and method for manufacturing optically active carbonyl compound using the same Takasago International Corporation (JP) 2012-05-30 EP disclosed
US-20100324338-A1 CATALYST FOR ASYMMETRIC HYDROGENATION TAKASAGO INTERNATIONAL CORPORATION (JP) 2010-12-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100324338-A1 CATALYST FOR ASYMMETRIC HYDROGENATION H1-0, H1-5, ADH5 HTT 3750/4885SCN1A 1157/4885SCN2A 2050/4885
US-20120136176-A1 CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBONYL COMPOUND USING THE SAME HMOX1, HIRA, HRH1 HTT 3531/4885SCN1A 1657/4885SCN2A 2891/4885
US-20130217895-A1 CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBONYL COMPOUND USING THE SAME HMOX1, NQO1, CBR3 HTT 3791/4885SCN1A 721/4885SCN2A 1606/4885
US-20130253228-A1 METHOD FOR MANUFACTURING OPTICALLY ACTIVE MENTHOL MSMO1, GGPS1, MAN1B1 HTT 3893/4885SCN1A 3305/4885SCN2A 4596/4885
US-20160222037-A1 USE OF CYCLOHEXA-2,5-DIEN-1-YL-SILANES AS PRECURSORS FOR GASEOUS HYDROSILANES HRH3, HRH2, HRH1 HTT 878/4885SCN1A 2579/4885SCN2A 1965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.