Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28409114 | 0.86 | SLC6A3 (0.36) | NPC1RAB9AL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL6846856 | 0.86 | FBP1 (0.37) | L3MBTL1KMOALDH1A1ALOX5CNR2 | |
| SCHEMBL28414541 | 0.77 | SLC6A3 (0.38) | L3MBTL1ALDH1A1CNR2MAPTMEN1 | |
| SCHEMBL28412341 | 0.73 | MEN1 (0.32) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL27718164 | 0.69 | POLB (0.31) | POLB | |
| SCHEMBL6850656 | 0.66 | CRHBP (0.34) | ALDH1A1TDP1 | |
| Bromide SCHEMBL6846809 | 0.65 | CRHBP (0.33) | — | |
| SCHEMBL27574427 | 0.63 | ALDH1A1 (0.31) | ALDH1A1POLB | |
| SCHEMBL28085588 | 0.60 | — | — | |
| SCHEMBL27718041 | 0.60 | POLB (0.32) | MAPTMEN1KMT2ANPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111087315-A | Synthetic method of eltrombopag intermediate and synthetic method of eltrombopag | 武汉武药科技有限公司 | 2020-05-01 | — | — | CN | claimed |
| CN-114072386-A | Improved process for the preparation of key intermediates for the synthesis of eltrombopag or salts thereof | F.I.S.-菲博利佳意大利合成面料股份公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-111087315-A | Synthetic method of eltrombopag intermediate and synthetic method of eltrombopag | 武汉武药科技有限公司 | 2020-05-01 | — | — | CN | disclosed |
| CN-111087315-A | Synthetic method of eltrombopag intermediate and synthetic method of eltrombopag | 武汉武药科技有限公司 | 2020-05-01 | — | — | CN | disclosed |