Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 8/20 | 0.51 |
| ▸ | MMP13 | P45452 | 3/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.51 |
| ▸ | MMP14 | P50281 | 2/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.51 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | CA9 | Q16790 | 6/20 | 0.50 |
| ▸ | TARS1 | P26639 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2841159 | 0.87 | ADRB2 (0.54) | ALDH1A1 | |
| SCHEMBL2840998 | 0.85 | PGR (0.60) | MMP1MMP2MMP13ADAMTS4MMP14 | |
| SCHEMBL2841047 | 0.81 | LMNA (0.54) | MMP1MMP2MMP13ADAMTS4MMP14 | |
| SCHEMBL2844722 | 0.78 | MMP2 (0.51) | MMP1MMP2MMP13ADAMTS4MMP14 | |
| SCHEMBL2843014 | 0.78 | MMP2 (0.51) | MMP1MMP2MMP13ADAMTS4MMP14 | |
| SCHEMBL2844724 | 0.78 | MMP2 (0.51) | MMP1MMP2MMP13ADAMTS4MMP14 | |
| SCHEMBL13621547 | 0.77 | GAA (0.51) | MMP1MMP2MMP13CA2CA9 | |
| SCHEMBL2842887 | 0.77 | TSHR (0.59) | ALDH1A1 | |
| SCHEMBL2846313 | 0.76 | ADRB3 (0.47) | MMP1MMP2MMP13ADAMTS4MMP14 | |
| SCHEMBL3502829 | 0.74 | ALDH1A1 (0.60) | MMP2MMP13CA2CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |