Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | MMP14 | P50281 | 2/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | TARS1 | P26639 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2843014 | 1.00 | MMP2 (0.51) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL2844722 | 1.00 | MMP2 (0.51) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL2840998 | 0.82 | PGR (0.60) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL2842136 | 0.78 | MMP1 (0.52) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL2840401 | 0.77 | MC4R (0.49) | L3MBTL1 | |
| SCHEMBL2839988 | 0.77 | MC4R (0.49) | L3MBTL1 | |
| SCHEMBL2839986 | 0.77 | MC4R (0.49) | L3MBTL1 | |
| SCHEMBL2841047 | 0.77 | LMNA (0.54) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL2841159 | 0.75 | ADRB2 (0.54) | L3MBTL1ADRB2ADRB1 | |
| SCHEMBL2323236 | 0.74 | ADRB1 (0.55) | CA2CA9L3MBTL1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |