SCHEMBL28458271

SCHEMBL28458271

CCB(O)Oc1ccc(C(F)(F)F)cc1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TRPV6 Q9H1D0 2/20 0.44
ORAI1 Q96D31 1/20 0.44
ORAI2 Q96SN7 1/20 0.44
ORAI3 Q9BRQ5 1/20 0.44
MGLL Q99685 1/20 0.44
MAOB P27338 5/20 0.40
ALDH1A1 P00352 1/20 0.39
KIF11 P52732 1/20 0.39
CYP1A1 P04798 2/20 0.38
CYP1B1 Q16678 2/20 0.38
AOC3 Q16853 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
CHRNB2 P17787 1/20 0.37
CHRNB4 P30926 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNA7 P36544 1/20 0.37
CHRNA4 P43681 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28321109 0.78 TRPV6 (0.52) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL646662 0.78 TRPV6 (0.52) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL20557365 0.78 ACHE (0.42) TRPV6ORAI1ORAI2ORAI3ALDH1A1
SCHEMBL7103574 0.76 TRPV6 (0.50) TRPV6ORAI1ORAI2ORAI3MGLL
Ammonia Solution, Strong SCHEMBL29013463 0.76 TRPV6 (0.50) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL28464653 0.75 LPL (0.48) ALDH1A1
SCHEMBL28454846 0.75 CA1 (0.38) MGLLMAOBALDH1A1CA1CA2
SCHEMBL2807977 0.74 LTA4H (0.39) ALDH1A1CA1CA2CHRNB2CHRNB4
SCHEMBL4442321 0.73 CA1 (0.47) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL30462559 0.73 KIF11 (0.53) TRPV6ORAI1ORAI2ORAI3MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111718363-B Preparation method of borate compound 中国科学院化学研究所 2021-07-13 CN disclosed
CN-111718363-A Preparation method of borate compound 中国科学院化学研究所 2020-09-29 CN disclosed