Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP5 | P45974 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028407 | 0.93 | NPC1 (0.32) | RBP4ALDH1A1POLB | |
| SCHEMBL10922111 | 0.80 | QDPR (0.40) | ALDH1A1POLB | |
| SCHEMBL28166840 | 0.80 | PDE4B (0.32) | — | |
| SCHEMBL1898647 | 0.80 | — | — | |
| SCHEMBL28056726 | 0.77 | NPC1 (0.41) | — | |
| SCHEMBL7375779 | 0.74 | GAA (0.53) | — | |
| SCHEMBL28056784 | 0.73 | PARP10 (0.46) | ALDH1A1POLB | |
| Acetic Acid SCHEMBL1666951 | 0.71 | CHRNB2 (0.30) | — | |
| SCHEMBL28056859 | 0.70 | FDFT1 (0.47) | ALDH1A1 | |
| SCHEMBL28056844 | 0.70 | LMNA (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2216021-B1 | PHARMACEUTICAL COMPOSITION FOR TREATING OVERACTIVE BLADDER | ASTELLAS PHARMA INC (JP) | 2012-10-17 | — | — | EP | disclosed |
| EP-2216021-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING OVERACTIVE BLADDER | Astellas Pharma Inc. (JP) | 2010-08-11 | — | — | EP | disclosed |