Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | MST1R | Q04912 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852605 | 0.90 | HPGD (0.37) | LMNAKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2855477 | 0.85 | MAPT (0.41) | KDM4EALDH1A1MAPTHPGDPOLB | |
| SCHEMBL2850855 | 0.83 | KEAP1 (0.36) | KDM4EALDH1A1MAPTHPGDPOLB | |
| SCHEMBL2853031 | 0.83 | MAPT (0.41) | KDM4EALDH1A1MAPTHPGDPOLB | |
| SCHEMBL2854678 | 0.83 | ATR (0.40) | KDM4EMAPTIRAK4 | |
| SCHEMBL2857444 | 0.81 | ALDH1A1 (0.42) | KDM4EALDH1A1MAPTMALT1RXFP1 | |
| SCHEMBL2861607 | 0.77 | TRPV1 (0.42) | SMN1; SMN2KMT2A | |
| SCHEMBL2858340 | 0.75 | MALT1 (0.42) | MALT1KMT2A | |
| SCHEMBL2857337 | 0.75 | KMT2A (0.43) | LMNAKDM4EMAPTCYP1A2MALT1 | |
| SCHEMBL2853241 | 0.75 | SMN1; SMN2 (0.41) | LMNAALDH1A1MAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |