Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854810 | 0.89 | KMT2A (0.46) | KMT2AMEN1MAPTHSP90AA1KDM4E | |
| SCHEMBL2855496 | 0.87 | KDM4E (0.46) | KMT2AMEN1MAPTHSP90AA1KDM4E | |
| SCHEMBL2854269 | 0.86 | RAB9A (0.46) | MAPTNPC1RAB9ALMNAMTOR | |
| SCHEMBL2854592 | 0.85 | MEN1 (0.40) | KMT2AMEN1MAPTHSP90AA1KDM4E | |
| SCHEMBL2854572 | 0.84 | RAB9A (0.44) | KMT2AMEN1MAPTHSP90AA1KDM4E | |
| SCHEMBL2854492 | 0.83 | MAPT (0.42) | KMT2AMEN1MAPTHSP90AA1KDM4E | |
| SCHEMBL2861646 | 0.82 | NPC1 (0.42) | KMT2AMEN1MAPTKDM4ENPSR1 | |
| SCHEMBL2861607 | 0.81 | TRPV1 (0.42) | KMT2AMEN1L3MBTL1P2RY1 | |
| SCHEMBL2855950 | 0.80 | POLB (0.41) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL2850733 | 0.78 | KEAP1 (0.46) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |