Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853031 | 0.89 | MAPT (0.41) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2859508 | 0.86 | CYP1A2 (0.46) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2852552 | 0.86 | MEN1 (0.51) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2848541 | 0.85 | RAB9A (0.43) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2854596 | 0.85 | TP53 (0.46) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2850855 | 0.85 | KEAP1 (0.36) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2850388 | 0.85 | LMNA (0.35) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2850610 | 0.85 | MAPT (0.40) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2857074 | 0.84 | LPAR1 (0.42) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2855775 | 0.83 | P2RY1 (0.44) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |