Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 11/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852605 | 0.87 | HPGD (0.37) | MALT1MAPTRXFP1KDM4EALDH1A1 | |
| SCHEMBL2855477 | 0.85 | MAPT (0.41) | MAPTKDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL2852387 | 0.84 | P2RX7 (0.37) | KEAP1NFE2L2MALT1MAPTRXFP1 | |
| SCHEMBL2850388 | 0.83 | LMNA (0.35) | MALT1MAPTRXFP1KDM4EALDH1A1 | |
| SCHEMBL2857955 | 0.83 | NPY5R (0.42) | KEAP1NFE2L2MALT1MAPTALDH1A1 | |
| SCHEMBL2853031 | 0.80 | MAPT (0.41) | MAPTKDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL2852553 | 0.79 | MALT1 (0.40) | KEAP1NFE2L2MALT1MAPTKDM4E | |
| SCHEMBL2856974 | 0.79 | MAPT (0.39) | KEAP1NFE2L2MALT1MAPTKDM4E | |
| SCHEMBL2852401 | 0.77 | L3MBTL1 (0.39) | RXFP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2854492 | 0.77 | MAPT (0.42) | MALT1MAPTKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |