Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859509 | 0.90 | KMT2A (0.54) | HTTSMN1; SMN2KMT2ANAMPTEPHX1 | |
| SCHEMBL2860234 | 0.90 | HPGD (0.54) | GAASMN1; SMN2DHODHMEN1KMT2A | |
| SCHEMBL2856499 | 0.89 | ALDH1A1 (0.53) | GAASMN1; SMN2KMT2ANPSR1KDM4E | |
| SCHEMBL2854531 | 0.84 | LMNA (0.52) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2854802 | 0.84 | LMNA (0.48) | GAATHRBMEN1KMT2ATP53 | |
| SCHEMBL2853389 | 0.82 | NPC1 (0.62) | GAASMN1; SMN2THRBKMT2ANPC1 | |
| SCHEMBL2861261 | 0.81 | HPGD (0.64) | GAASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2857338 | 0.80 | RAB9A (0.47) | GAASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2853335 | 0.80 | TP53 (0.48) | GAASMN1; SMN2THRBNPC1RAB9A | |
| SCHEMBL2856862 | 0.79 | NPC1 (0.53) | GAASMN1; SMN2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |