Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858097 | 0.91 | P2RX7 (0.53) | TP53MAPTNPC1RAB9AP2RX7 | |
| SCHEMBL2858680 | 0.90 | NPC1 (0.45) | TP53MAPK8MAPTSMN1; SMN2NPC1 | |
| SCHEMBL2850369 | 0.89 | P2RX7 (0.56) | TP53MAPK8MAPTP2RX7PKM | |
| SCHEMBL2857338 | 0.88 | RAB9A (0.47) | MAPTSMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL2860234 | 0.85 | HPGD (0.54) | TP53MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2854531 | 0.84 | LMNA (0.52) | TP53MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2856505 | 0.84 | TP53 (0.59) | TP53MAPK8MAPTSMN1; SMN2NPC1 | |
| SCHEMBL2852417 | 0.82 | MAPT (0.49) | TP53MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2850323 | 0.82 | MAPT (0.47) | TP53MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2856602 | 0.81 | RIPK1 (0.46) | TP53MAPTP2RX7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |