Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | GPR6 | P46095 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858182 | 0.88 | P2RX7 (0.44) | MAPTLMNAP2RX7POLBALDH1A1 | |
| SCHEMBL2848541 | 0.88 | RAB9A (0.43) | MAPTGPR6ACHELMNAP2RX7 | |
| SCHEMBL2857353 | 0.87 | CCR1 (0.47) | MAPTGPR6ACHEP2RX7CCR1 | |
| SCHEMBL2854533 | 0.86 | MEN1 (0.46) | MAPTGPR6ACHELMNATRPC1 | |
| SCHEMBL2857550 | 0.86 | TMPRSS4 (0.45) | MAPTGPR6ACHEORAI1P2RX7 | |
| SCHEMBL2852244 | 0.85 | MAPT (0.48) | MAPTGPR6ACHETRPC1TRPC3 | |
| SCHEMBL2852552 | 0.84 | MEN1 (0.51) | MAPTGPR6ACHEP2RX7SMN1; SMN2 | |
| SCHEMBL2856901 | 0.84 | MAPT (0.40) | MAPTGPR6ACHELMNAP2RX7 | |
| SCHEMBL2853465 | 0.84 | RAB9A (0.44) | MAPTGPR6ACHELMNATRPC1 | |
| SCHEMBL2853154 | 0.83 | MAPT (0.44) | MAPTGPR6ACHELMNATRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |