Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857758 | 0.85 | TRPV1 (0.41) | TRPV1MAPK1HIF1ANPC1RAB9A | |
| SCHEMBL2856479 | 0.85 | MAPK1 (0.41) | TRPV1MAPK1HIF1ANPC1RAB9A | |
| SCHEMBL2857936 | 0.85 | KDM4E (0.47) | TRPV1MAPK1HIF1AKDM4EKMT2A | |
| SCHEMBL2857979 | 0.84 | TRPV1 (0.39) | TRPV1MAPK1HIF1ANPC1RAB9A | |
| SCHEMBL2848513 | 0.83 | P2RX7 (0.43) | TRPV1MAPK1HIF1AKDM4ESCN9A | |
| SCHEMBL2858012 | 0.81 | CNR1 (0.46) | TRPV1MAPK1HIF1ACNR1KDM4E | |
| SCHEMBL2852183 | 0.79 | TAAR1 (0.44) | NPC1RAB9AKDM4ELTA4HEPHX2 | |
| SCHEMBL2857615 | 0.77 | MTOR (0.37) | TRPV1NPC1RAB9A | |
| SCHEMBL2860131 | 0.74 | ALDH1A1 (0.46) | KDM4EKMT2A | |
| SCHEMBL2856697 | 0.74 | KDM4E (0.46) | TRPV1HIF1ACNR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |