Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2849954 | 0.90 | MAPT (0.46) | GRM5MAPTRAB9ANTRK1POLB | |
| SCHEMBL2858621 | 0.87 | MAPT (0.48) | GRM5MAPTRAB9ANTRK1POLB | |
| SCHEMBL2860487 | 0.85 | NTRK1 (0.42) | GRM5MAPTRAB9ANTRK1POLB | |
| SCHEMBL2855950 | 0.78 | POLB (0.41) | MAPTRAB9APOLBMAPK14KEAP1 | |
| SCHEMBL2852952 | 0.76 | SMN1; SMN2 (0.38) | MAPTRAB9APOLBNPSR1MAPK14 | |
| SCHEMBL2852941 | 0.75 | POLB (0.44) | MAPTRAB9APOLBCACNA1GCACNA1H | |
| SCHEMBL2855716 | 0.75 | KEAP1 (0.46) | MAPTRAB9APOLBKEAP1NFE2L2 | |
| SCHEMBL2848489 | 0.73 | POLB (0.44) | MAPTRAB9APOLBMAPK14KEAP1 | |
| SCHEMBL2854269 | 0.73 | RAB9A (0.46) | MAPTRAB9APOLBALDH1A1 | |
| SCHEMBL2850725 | 0.73 | MAPT (0.54) | MAPTPOLBNPSR1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |