Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853814 | 0.89 | LIPE (0.43) | POLBLIPEALDH1A1KDM4EKEAP1 | |
| SCHEMBL2852844 | 0.84 | LIPE (0.45) | POLBLIPEALDH1A1KDM4ECCR1 | |
| SCHEMBL2859967 | 0.83 | KEAP1 (0.52) | POLBALDH1A1KDM4ECCR1KEAP1 | |
| SCHEMBL2858320 | 0.81 | TP53 (0.48) | MEN1KMT2A | |
| SCHEMBL2852941 | 0.81 | POLB (0.44) | POLBALDH1A1KDM4ECCR1KEAP1 | |
| SCHEMBL2860476 | 0.79 | CCR1 (0.54) | LIPEKDM4ECCR1MAPT | |
| SCHEMBL2853061 | 0.77 | KDM4E (0.44) | POLBALDH1A1KDM4ECCR1KEAP1 | |
| SCHEMBL2862837 | 0.76 | CCR1 (0.61) | KDM4ECCR1 | |
| SCHEMBL2856483 | 0.74 | ALDH1A1 (0.45) | POLBALDH1A1KDM4ECCR1SMN1; SMN2 | |
| SCHEMBL2856128 | 0.73 | GRM5 (0.46) | POLBALDH1A1KDM4EKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |