Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 11/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854184 | 0.91 | CHRM4 (0.46) | CHRM4KCNH2SIGMAR1 | |
| SCHEMBL2858617 | 0.86 | CHRM4 (0.58) | CHRM4ACHECCR5 | |
| SCHEMBL2848489 | 0.81 | POLB (0.44) | MEN1KMT2A | |
| SCHEMBL2850713 | 0.77 | CHRM4 (0.46) | CHRM4ACHEKCNH2SIGMAR1DRD2 | |
| SCHEMBL2852941 | 0.74 | POLB (0.44) | TP53 | |
| SCHEMBL2854763 | 0.73 | DRD4 (0.50) | ACHESIGMAR1DRD2DRD4 | |
| SCHEMBL2854149 | 0.72 | TP53 (0.50) | TP53MEN1KMT2ASIGMAR1 | |
| SCHEMBL2859595 | 0.71 | CHRM4 (0.53) | CHRM4ACHEDRD2DRD4 | |
| SCHEMBL2859967 | 0.71 | KEAP1 (0.52) | — | |
| SCHEMBL2857724 | 0.71 | SIGMAR1 (0.53) | CHRM4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |