Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19408671 | 0.83 | PPARA (0.41) | PPARATSHRALDH1A1 | |
| SCHEMBL8903595 | 0.83 | PPARA (0.41) | PPARATSHRALDH1A1 | |
| SCHEMBL28052418 | 0.78 | ALDH1A1 (0.37) | PPARATSHRALDH1A1 | |
| SCHEMBL27974509 | 0.77 | ALDH1A1 (0.39) | TSHRALDH1A1 | |
| SCHEMBL6422713 | 0.75 | TSHR (0.37) | TSHRALDH1A1 | |
| Potassium Ion SCHEMBL11526209 | 0.73 | CA2 (0.47) | TSHRCYP3A4NFKB1NPSR1 | |
| Potassium Ion SCHEMBL1693886 | 0.72 | CYP3A4 (0.40) | TSHRCYP3A4NFKB1NPSR1ALDH1A1 | |
| SCHEMBL28761792 | 0.72 | THRB (0.32) | PPARA | |
| SCHEMBL9788016 | 0.71 | ALDH1A1 (0.31) | PPARATSHRALDH1A1 | |
| SCHEMBL9316254 | 0.70 | THRB (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473484-B | Compounds useful as TRPM8 modulators | 弗门尼舍公司 | 2021-06-29 | — | — | CN | disclosed |