Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ERG | P11308 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.43 |
| ▸ | ITGAL | P20701 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28620970 | 0.89 | MAPT (0.49) | GPR183ITGB2ICAM1ITGALGAA | |
| SCHEMBL28634881 | 0.89 | GAA (0.48) | GPR183NPC1RAB9AGAAMAPT | |
| SCHEMBL28616300 | 0.87 | GPR183 (0.51) | GPR183SMN1; SMN2 | |
| SCHEMBL28620396 | 0.87 | LMNA (0.48) | GPR183NPC1MAPTKDM4ECCNC | |
| SCHEMBL28620401 | 0.87 | GPR183 (0.55) | GPR183NPC1RAB9AMAPT | |
| SCHEMBL28627421 | 0.86 | L3MBTL1 (0.54) | NPC1TDP1GAAMAPTL3MBTL1 | |
| SCHEMBL28620716 | 0.85 | MAPT (0.45) | GPR183NPC1GAAMAPTL3MBTL1 | |
| SCHEMBL28617767 | 0.85 | L3MBTL1 (0.55) | GPR183NPC1RAB9AGAAMAPT | |
| SCHEMBL28617649 | 0.85 | LMNA (0.48) | GPR183NPC1RAB9AGAAMAPT | |
| SCHEMBL28630175 | 0.85 | SMN1; SMN2 (0.51) | GPR183NPC1RAB9AERGSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440440-B | Naphthalene ring-containing 1,2, 4-oxadiazole-cinnamoyl piperazine compound and preparation method and application thereof | 贵州医科大学 | 2021-07-13 | — | — | CN | disclosed |