Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | GPR183 | P32249 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CCNC | P24863 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28634881 | 0.92 | GAA (0.48) | LMNAMAPTGPR183NPC1HTT | |
| SCHEMBL28620716 | 0.91 | MAPT (0.45) | LMNAMAPTGPR183NPC1HTT | |
| SCHEMBL28620401 | 0.91 | GPR183 (0.55) | LMNAMAPTGPR183NPC1KCNH2 | |
| SCHEMBL28616300 | 0.91 | GPR183 (0.51) | LMNAGPR183KCNH2TP53HPGD | |
| SCHEMBL28615982 | 0.88 | MAPT (0.52) | LMNAMAPTGPR183NPC1HTT | |
| SCHEMBL28617479 | 0.88 | STAT3 (0.52) | LMNAMAPTGPR183NPC1HTT | |
| SCHEMBL28627421 | 0.87 | L3MBTL1 (0.54) | LMNAMAPTNPC1HTTTHRB | |
| SCHEMBL28633212 | 0.87 | ALDH1A1 (0.53) | LMNAMAPTGPR183HTTHPGD | |
| SCHEMBL28620945 | 0.87 | GPR183 (0.50) | MAPTGPR183NPC1CCNCCDK8 | |
| SCHEMBL28617649 | 0.85 | LMNA (0.48) | LMNAMAPTGPR183NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440440-B | Naphthalene ring-containing 1,2, 4-oxadiazole-cinnamoyl piperazine compound and preparation method and application thereof | 贵州医科大学 | 2021-07-13 | — | — | CN | disclosed |