SCHEMBL28625936

SCHEMBL28625936

CCc1cc(C)cc(CC)c1CC(C#N)C#N

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.33
ALOX12 P18054 1/20 0.33
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL509853 0.74 THRB (0.34) ALDH1A1MAPTHTT
SCHEMBL3085420 0.72 POLB (0.33) ALOX15ALOX12ALDH1A1MAPTHTT
SCHEMBL3025730 0.71 DHFR (0.36) ALOX15ALOX12ALDH1A1MAPTHTT
SCHEMBL28619366 0.71 ALOX15 (0.38) ALOX15ALOX12ALDH1A1MAPTHTT
SCHEMBL16883661 0.69 KDM4E (0.41) ALOX15ALDH1A1MAPTHTT
Alcohol SCHEMBL28897134 0.68 POLB (0.34) ALOX15ALOX12ALDH1A1MAPTHTT
SCHEMBL28670458 0.67 KMT2A (0.31) ALDH1A1HTT
SCHEMBL508950 0.66 ALDH1A1 (0.38) ALOX15ALOX12ALDH1A1HTT
SCHEMBL1224583 0.66 KMT2A (0.32) ALOX15ALOX12ALDH1A1HTT
SCHEMBL509831 0.66 KMT2A (0.35) ALOX15ALOX12ALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113321583-A Preparation method and application of 2, 6-diethyl-4-methyl phenyl malonic acid diester 利尔化学股份有限公司 2021-08-31 CN disclosed