Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28668562 | 0.91 | DPP8 (0.48) | TDP1HPGDACENOTUMDPP8 | |
| SCHEMBL28676326 | 0.85 | NAMPT (0.44) | TDP1HPGD | |
| SCHEMBL14946437 | 0.81 | HPGD (0.63) | TDP1HPGDACEABHD6NOTUM | |
| SCHEMBL28655184 | 0.81 | TDP1 (0.63) | TDP1HPGDACEABHD6NOTUM | |
| SCHEMBL29758964 | 0.78 | CTSK (0.56) | TDP1HPGDACEABHD6NOTUM | |
| SCHEMBL18215088 | 0.78 | CTSK (0.56) | TDP1HPGDACEABHD6NOTUM | |
| SCHEMBL28650975 | 0.78 | CTSK (0.56) | TDP1HPGDACEABHD6NOTUM | |
| SCHEMBL3194583 | 0.77 | RAB9A (0.61) | NOTUMALDH1A1TP53KMT2AMAPT | |
| SCHEMBL28670701 | 0.77 | DRD2 (0.53) | — | |
| SCHEMBL10422997 | 0.76 | ACE (0.67) | TDP1HPGDACENOTUMDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107735088-B | Histone deacetylase inhibitors, compositions and methods of use thereof | CHDI基金会股份有限公司 | 2021-11-02 | — | — | CN | disclosed |