Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286328 | 1.00 | KMT2A (0.38) | KMT2AL3MBTL1USP2GAAHPGD | |
| SCHEMBL286414 | 0.91 | GABRA1 (0.32) | KMT2AL3MBTL1GABRA5GABRA1ALDH1A1 | |
| SCHEMBL286463 | 0.87 | ALDH1A1 (0.34) | KMT2AL3MBTL1GAASMN1; SMN2GABRA5 | |
| SCHEMBL286460 | 0.86 | ALPL (0.43) | KMT2AL3MBTL1GABRA5ALDH1A1ALPL | |
| SCHEMBL286337 | 0.84 | HCAR2 (0.39) | L3MBTL1GAAGABRA5HTTALPL | |
| SCHEMBL286160 | 0.84 | GABRA5 (0.42) | GABRA5GABRA1 | |
| SCHEMBL286261 | 0.82 | GABRA1 (0.46) | KMT2AGABRA1 | |
| SCHEMBL286575 | 0.82 | GABRA1 (0.46) | KMT2AGABRA1 | |
| SCHEMBL286719 | 0.82 | GABRA1 (0.46) | KMT2AGABRA1 | |
| SCHEMBL286080 | 0.81 | GABRA5 (0.44) | GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |