Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | LIPA | P38571 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29797073 | 0.81 | KMT2A (0.44) | KMT2AMEN1HSD17B10ALDH1A1POLB | |
| SCHEMBL30449933 | 0.75 | ALDH1A1 (0.50) | KMT2AMEN1HSD17B10ALDH1A1POLB | |
| SCHEMBL38657830 | 0.73 | ALDH1A1 (0.47) | KMT2AMEN1HSD17B10ALDH1A1POLB | |
| SCHEMBL30678682 | 0.69 | ALDH1A1 (0.50) | KMT2AMEN1HSD17B10ALDH1A1POLB | |
| SCHEMBL11150108 | 0.68 | ALDH1A1 (0.53) | KMT2AMEN1HSD17B10ALDH1A1POLB | |
| SCHEMBL30473912 | 0.67 | ALDH1A1 (0.56) | KMT2AMEN1HSD17B10ALDH1A1POLB | |
| SCHEMBL30405057 | 0.67 | THRB (0.34) | KMT2AMEN1HSD17B10SMN1; SMN2L3MBTL1 | |
| SCHEMBL31127701 | 0.67 | ALDH1A1 (0.51) | KMT2AMEN1HSD17B10ALDH1A1POLB | |
| SCHEMBL13480992 | 0.66 | ALDH1A1 (0.54) | KMT2AMEN1HSD17B10ALDH1A1POLB | |
| SCHEMBL31589528 | 0.66 | ALDH1A1 (0.50) | KMT2AMEN1HSD17B10ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | Evotec International GmbH (DE) | 2023-08-30 | — | — | EP | claimed |
| WO-2022084447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2022-04-28 | — | — | WO | claimed |
| CN-119677733-A | Bicyclic tetrahydrothiazepine derivatives | 豪夫迈·罗氏有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-113993850-A | Modulators of integrated stress response pathways | 埃沃特克国际有限责任公司 | 2022-01-28 | — | — | CN | disclosed |