Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.34 |
| ▸ | ABAT | P80404 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435100 | 0.82 | — | — | |
| Trifluoroacetic Acid SCHEMBL28658095 | 0.80 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1POLBKDM4EALDH5A1 | |
| SCHEMBL18810073 | 0.75 | L3MBTL1 (0.49) | ALDH1A1L3MBTL1POLBKDM4EAPP | |
| SCHEMBL1267742 | 0.75 | L3MBTL1 (0.57) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL29417154 | 0.75 | L3MBTL1 (0.57) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL336320 | 0.70 | TRPV4 (0.52) | ALDH1A1L3MBTL1POLBKDM4EKCNJ1 | |
| SCHEMBL29417132 | 0.70 | TRPV4 (0.52) | ALDH1A1L3MBTL1POLBKDM4EKCNJ1 | |
| SCHEMBL245370 | 0.68 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1POLBKDM4ELMNA | |
| SCHEMBL6826159 | 0.68 | L3MBTL1 (0.38) | ALDH1A1L3MBTL1POLBKDM4EAPP | |
| SCHEMBL31737439 | 0.68 | ALDH5A1 (0.46) | ALDH1A1KDM4EALDH5A1ABATLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163437-A | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2022-03-11 | — | — | CN | disclosed |