Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27516569 | 0.87 | LMNA (0.53) | LMNAGAAHDAC1HDAC8HDAC6 | |
| SCHEMBL27539135 | 0.83 | LMNA (0.40) | HPGDLMNAGAAHDAC1HDAC8 | |
| SCHEMBL6433569 | 0.80 | HDAC1 (0.48) | HDAC1HDAC8HDAC6ERCC5FEN1 | |
| SCHEMBL27515881 | 0.78 | NPC1 (0.39) | HPGDLMNAGAAMAPTALDH1A1 | |
| SCHEMBL28787697 | 0.78 | FFAR1 (0.46) | LMNAMAPTALDH1A1FFAR1NPC1 | |
| SCHEMBL17360640 | 0.74 | HDAC1 (0.54) | HPGDLMNAHDAC1HDAC8HDAC6 | |
| SCHEMBL7220780 | 0.73 | ENPP3 (0.49) | ERCC5FEN1MAPTNPC1POLB | |
| SCHEMBL6438972 | 0.71 | HPGDS (0.47) | HPGDHDAC1HDAC8HDAC6ERCC5 | |
| SCHEMBL4640428 | 0.70 | MAPK1 (0.47) | HPGDLMNAMAPTALDH1A1NPC1 | |
| SCHEMBL4639858 | 0.70 | S1PR1 (0.47) | HPGDLMNAMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1268626-C | Dihydro-benzo(b)(1,4)diazepin-2-one derivatives as mglur2 antagonists I | HOFFMANN LA ROCHE (CH) | 2006-08-09 | — | — | CN | disclosed |
| CN-1522252-A | Dihydro-benzo(b)(1,4)diazepin-2-one derivatives as mglur2 antagonists I | - | 2004-08-18 | — | — | CN | disclosed |