Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27621509 | 0.98 | KDM4E (0.78) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL267885 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL17212260 | 0.88 | ALDH1A1 (0.81) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL10933445 | 0.85 | ALDH1A1 (0.95) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL4735417 | 0.84 | GAA (0.76) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL3660975 | 0.84 | ALDH1A1 (0.93) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL3656127 | 0.83 | ALDH1A1 (0.91) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL264913 | 0.83 | ALDH1A1 (0.91) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL3659209 | 0.83 | ALDH1A1 (0.91) | ALDH1A1KDM4EPOLBGAAMEN1 | |
| SCHEMBL29226741 | 0.82 | ALDH1A1 (0.77) | ALDH1A1KDM4EPOLBGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1752089-A | Preparation method of high-melting-point 3-dibutylamino-6-methyl-7-anilinofluorane | KANGAITE WEIXUN PENGLAI CHEMIC (CN) | 2006-03-29 | — | — | CN | disclosed |