Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 15/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24660110 | 0.86 | ASPH (0.40) | CNR2PDCD1CD274TRPC6CNR1 | |
| SCHEMBL24660032 | 0.76 | MAPT (0.44) | CNR2TRPC6 | |
| SCHEMBL29558234 | 0.72 | PDCD1 (0.63) | PDCD1CD274 | |
| SCHEMBL24446141 | 0.72 | PDCD1 (0.63) | PDCD1CD274 | |
| SCHEMBL24446475 | 0.70 | — | — | |
| SCHEMBL24446151 | 0.69 | PDCD1 (0.61) | PDCD1CD274 | |
| SCHEMBL30620087 | 0.65 | SIRT6 (0.35) | — | |
| SCHEMBL22346487 | 0.65 | SIRT6 (0.35) | — | |
| SCHEMBL21616774 | 0.64 | GPR35 (0.43) | — | |
| SCHEMBL30340453 | 0.64 | GPR35 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113825751-A | Biphenyl derivative for blocking PD-1/PD-L1 interaction and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2021-12-21 | — | — | CN | disclosed |