SCHEMBL28822189

SCHEMBL28822189

Brc1cccc(N2Cc3ccccc3C=N2)c1

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 3/20 0.37
MGLL Q99685 1/20 0.36
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
ALDH1A1 P00352 1/20 0.34
ALOX5 P09917 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
ATM Q13315 1/20 0.33
DHFR P00374 2/20 0.32
BRD2 P25440 1/20 0.32
DCTPP1 Q9H773 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28890342 0.83 TRPA1 (0.33) TRPA1MEN1KMT2AALDH1A1
SCHEMBL28408861 0.82 TRPA1 (0.40) TRPA1MEN1KMT2AALDH1A1L3MBTL1
SCHEMBL28404573 0.82 ALDH1A1 (0.40) MGLLMEN1KMT2AALDH1A1ALOX5
SCHEMBL28409512 0.82 CASP6 (0.40) MGLLMEN1KMT2AALDH1A1
SCHEMBL28409989 0.82 ALDH1A1 (0.39) TRPA1MGLLALDH1A1
SCHEMBL28409571 0.79 MAPT (0.40) MGLLALDH1A1
SCHEMBL28412512 0.78 ALDH1A1 (0.56) KMT2AALDH1A1ALOX5L3MBTL1
SCHEMBL28407412 0.78 DRD2 (0.42) TRPA1ALDH1A1ALOX5
SCHEMBL28403820 0.75 HSD17B3 (0.37) TRPA1
SCHEMBL28416960 0.74 RAB9A (0.41) TRPA1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111116487-B Phthalazine compound, and synthetic method and application thereof 西北农林科技大学 2022-08-23 CN claimed
CN-111116487-B Phthalazine compound, and synthetic method and application thereof 西北农林科技大学 2022-08-23 CN disclosed