Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 3/20 | 0.32 |
| ▸ | PTPRC | P08575 | 2/20 | 0.32 |
| ▸ | S100A4 | P26447 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7633795 | 0.71 | TSHR (0.48) | KMT2AMEN1TDP2NSD2ABL1 | |
| SCHEMBL16550314 | 0.67 | CYP11B2 (0.36) | KMT2AMEN1TDP2NSD2ABL1 | |
| SCHEMBL802342 | 0.67 | PDK2 (0.36) | KMT2AMEN1TDP2NSD2ABL1 | |
| SCHEMBL28328181 | 0.65 | KMT2A (0.31) | KMT2AMEN1TDP2NSD2ABL1 | |
| SCHEMBL8512088 | 0.65 | S100A4 (0.45) | TRIM24TRIM33KMT2AMEN1TDP2 | |
| SCHEMBL22579802 | 0.64 | TDP1 (0.42) | KMT2AMEN1TDP2NSD2ABL1 | |
| SCHEMBL585349 | 0.64 | TDP1 (0.42) | KMT2AMEN1TDP2NSD2ABL1 | |
| SCHEMBL890949 | 0.63 | S100A4 (0.43) | TRIM24TRIM33KMT2AMEN1TDP2 | |
| SCHEMBL27431306 | 0.63 | SIGMAR1 (0.35) | CDC25BCYP2A6ERN1 | |
| SCHEMBL27416904 | 0.63 | NOS2 (0.55) | KMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |