SCHEMBL585349

SCHEMBL585349

c1cnc2c(c1)-c1cccnc1C2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.42
BLM P54132 2/20 0.42
TDP2 O95551 1/20 0.42
NSD2 O96028 1/20 0.42
ABL1 P00519 1/20 0.42
PLCG1 P19174 1/20 0.42
CES1 P23141 1/20 0.42
PAX8 Q06710 1/20 0.42
RIN1 Q13671 1/20 0.42
MEN1 O00255 1/20 0.42
THRB P10828 1/20 0.42
KMT2A Q03164 1/20 0.42
GAA P10253 1/20 0.42
CCR1 P32246 4/20 0.42
CCR8 P51685 4/20 0.42
KDM4E B2RXH2 3/20 0.42
MAPT P10636 2/20 0.42
LMNA P02545 2/20 0.42
CCR5 P51681 2/20 0.42
HIF1A Q16665 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10253865 0.85 TDP1 (0.37) TDP1BLMTDP2NSD2ABL1
SCHEMBL17264313 0.85 TDP1 (0.33) TDP1BLMTDP2NSD2ABL1
SCHEMBL29360004 0.84 METAP2 (0.46) CES1KDM4EMAPTLMNAHIF1A
SCHEMBL27174135 0.84 METAP2 (0.46) CES1KDM4EMAPTLMNAHIF1A
SCHEMBL17264311 0.84 KMT2A (0.45) TDP1BLMTDP2NSD2ABL1
SCHEMBL30011414 0.84 METAP2 (0.46) CES1KDM4EMAPTLMNAHIF1A
SCHEMBL51294 0.84 METAP2 (0.46) CES1KDM4EMAPTLMNAHIF1A
SCHEMBL22579802 0.83 TDP1 (0.42) TDP1BLMTDP2NSD2ABL1
SCHEMBL9963984 0.80 PTPRC (0.46) TDP1BLMTDP2NSD2ABL1
SCHEMBL14452870 0.79 LMNA (0.33) TDP1BLMTDP2NSD2ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11818948-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-11-14 US disclosed
US-11608333-B2 Composition of matter for use in organic light-emitting diodes KYULUX, INC. (JP) 2023-03-21 US disclosed
US-20220143201-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT NEKTAR THERAPEUTICS (US) 2022-05-12 US disclosed
US-20200276320-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT NEKTAR THERAPEUTICS (US) 2020-09-03 US disclosed
US-10695435-B2 Composition comprising a polymeric reagent NEKTAR THERAPEUTICS (US) 2020-06-30 US disclosed
US-20180226580-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION 2018-08-09 US disclosed
US-20180145264-A1 Organic Electroluminescent Device; A Charge Transporting Material For The Organic Electroluminescent Device; And A Luminescent Device, A Display Device And A Lighting System Using The Organic Electroluminescent Device UDC IRELAND LTD (IE) 2018-05-24 US disclosed
US-20180138413-A1 DENDRIMER COMPOUND AND ORGANIC LUMINESCENT DEVICE EMPLOYING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-05-17 US disclosed
US-9966532-B2 Dendrimer compound and organic luminescent device employing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-05-08 US disclosed
US-20180006247-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2018-01-04 US disclosed
WO-2010118078-A1 MACROCYCLIC SERINE PROTEASE INHIBITORS IDENIX PHARMACEUTICALS, INC. (US) 2010-10-14 WO disclosed
EP-1645552-B1 Electroluminescent devices made with double-spiro organic compounds LG CHEMICAL LTD (KR) 2010-05-05 EP disclosed
WO-2008011165-A2 POLYMERIC REAGENTS COMPRISING A TERMINAL VINYLIC GROUP AND CONJUGATES FORMED THEREFROM NEKTAR THERAPEUTICS AL, CORPORATION (US) 2008-01-24 WO disclosed
US-20070154732-A1 Dendrimer compound and organic luminescent device employing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-07-05 US disclosed
US-5434264-A α,α-disubstituted aromatics and heteroaromatics as cognition enhancers THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-07-18 US disclosed
US-5300642-A α, α-disubstituted aromatics and heteroaromatics as cognition enhancers THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-04-05 US disclosed
EP-0311010-B1 Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers DU PONT MERCK PHARMA (US) 1994-02-02 EP disclosed
EP-0532054-A1 Process for preparing alpha,alpha-disubstituted aromatics and heteroaromatics as cognition enhancers THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP disclosed
US-5173489-A α,α-disubstituted aromatics and heteroaromatics as cognition enhancers THE DUPONT MERCK PHARMACEUTICAL CO. (US) 1992-12-22 US disclosed
EP-0311010-A2 Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1989-04-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180145264-A1 Organic Electroluminescent Device; A Charge Transporting Material For The Organic Electroluminescent Device; And A Luminescent Device, A Display Device And A Lighting System Using The Organic Electroluminescent Device SLC43A1, SLC6A19, AOC3 TDP1 3315/4885BLM 2591/4885TDP2 3492/4885
US-20220143201-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT CD44, FCGRT, C9 TDP1 3527/4885BLM 967/4885TDP2 3531/4885
US-20200276320-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT CD44, FCGRT, C9 TDP1 3527/4885BLM 967/4885TDP2 3531/4885
US-20180138413-A1 DENDRIMER COMPOUND AND ORGANIC LUMINESCENT DEVICE EMPLOYING THE SAME DCUN1D4, DCUN1D1, FLOT1 TDP1 683/4885BLM 2466/4885TDP2 1299/4885
US-11608333-B2 Composition of matter for use in organic light-emitting diodes CRY2, SLCO1B3, NDUFV3 TDP1 503/4885BLM 182/4885TDP2 309/4885
US-11818948-B2 Organic electroluminescent materials and devices SLCO4C1, SLC29A1, SLC29A2 TDP1 1870/4885BLM 1009/4885TDP2 1598/4885
US-20180006247-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES TYR, YAP1, PAXBP1 TDP1 2268/4885BLM 216/4885TDP2 1927/4885
US-20180226580-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES SLCO4C1, SLCO2A1, SLCO2B1 TDP1 2794/4885BLM 1204/4885TDP2 2480/4885
US-10695435-B2 Composition comprising a polymeric reagent CD44, FCGRT, C9 TDP1 3527/4885BLM 967/4885TDP2 3531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.