Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10842060 | 0.85 | KMT2A (0.67) | KMT2AMEN1ALDH1A1KDM4ETHRB | |
| SCHEMBL21246906 | 0.78 | L3MBTL1 (0.59) | KMT2AMEN1KDM4EL3MBTL1CREBBP | |
| SCHEMBL6123415 | 0.78 | KDM4E (0.41) | KMT2AMEN1ALDH1A1KDM4ETHRB | |
| SCHEMBL1333179 | 0.76 | HTT (0.54) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28120658 | 0.76 | KMT2A (0.41) | KMT2AMEN1ALDH1A1KDM4ETHRB | |
| SCHEMBL28455877 | 0.73 | KMT2A (0.39) | KMT2AMEN1ALDH1A1KDM4ETHRB | |
| SCHEMBL27617492 | 0.72 | PKM (0.48) | KMT2AMEN1ALDH1A1KDM4ETHRB | |
| SCHEMBL28512335 | 0.70 | KDM4E (0.39) | KMT2AMEN1ALDH1A1KDM4ETHRB | |
| SCHEMBL8076272 | 0.69 | KMT2A (0.67) | KMT2AMEN1ALDH1A1KDM4ETHRB | |
| SCHEMBL8076273 | 0.69 | KMT2A (0.67) | KMT2AMEN1ALDH1A1KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189505-B | Tricyclic gyrase inhibitors as antibacterial agents | 默克夏普&多梅有限公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-105189505-A | Tricyclic gyrase inhibitors as antibacterial agents | TRIUS THERAPEUTICS INC | 2015-12-23 | — | — | CN | disclosed |