Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28871210 | 0.87 | ALDH1A1 (0.34) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL28462605 | 0.85 | KCNA3 (0.37) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL23701036 | 0.79 | TDP1 (0.37) | ALDH1A1KCNA3 | |
| SCHEMBL28797993 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KCNA3 | |
| SCHEMBL23701154 | 0.77 | KCNA3 (0.31) | KCNA3 | |
| SCHEMBL3481818 | 0.77 | LMNA (0.39) | ALDH1A1HPGDKCNA3 | |
| SCHEMBL31229726 | 0.76 | CA2 (0.41) | ALDH1A1HPGD | |
| SCHEMBL4454040 | 0.76 | CA1 (0.42) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL864473 | 0.74 | LTA4H (0.47) | ALDH1A1HPGD | |
| SCHEMBL5382089 | 0.74 | KCNA3 (0.54) | ALDH1A1KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117500811-A | Covalent RAS inhibitors and uses thereof | 锐新医药公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116209438-A | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors | 锐新医药公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115916194-A | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115873020-A | RAS inhibitors | 锐新医药公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-114980976-A | Covalent RAS inhibitors and uses thereof | 锐新医药公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-114901366-A | RAS inhibitors | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |