Phenazine

Phenazine

SCHEMBL28835271

O=S(=O)(O)O.[KH].c1ccc2nc3ccccc3nc2c1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.61
ALDH1A1 P00352 7/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
NQO2 P16083 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.47
KMT2A Q03164 3/20 0.44
RAB9A P51151 3/20 0.44
GAA P10253 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
NPC1 O15118 3/20 0.44
POLB P06746 2/20 0.44
MEN1 O00255 2/20 0.44
USP2 O75604 1/20 0.44
CACNA1B Q00975 1/20 0.44
APBA1 Q02410 1/20 0.44
HPGD P15428 3/20 0.43
HSD17B10 Q99714 2/20 0.43
KDM4E B2RXH2 2/20 0.43
GLA P06280 1/20 0.43
ACHE P22303 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenazine SCHEMBL8564741 0.97 MAPT (0.65) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Phenazine SCHEMBL2923781 0.97 MAPT (0.65) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Phenazine SCHEMBL23522711 0.86 MAPT (0.58) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Phenazine SCHEMBL1750964 0.86 MAPT (0.58) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Phenazine SCHEMBL23522712 0.86 MAPT (0.58) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Phenazine SCHEMBL28658053 0.84 MAPT (0.55) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Phenazine SCHEMBL28366239 0.84 MAPT (0.55) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Phenazine SCHEMBL22631548 0.84 MAPT (0.55) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Acridine SCHEMBL10831095 0.82 ALDH1A1 (0.71) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1
Acridine SCHEMBL11600717 0.82 ALDH1A1 (0.71) MAPTALDH1A1SMN1; SMN2NQO2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115027113-A Door and window sealing rubber strip and preparation method thereof 常州窗友塑胶有限公司 2022-09-09 CN disclosed