Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426140 | 0.80 | NPC1 (0.31) | — | |
| SCHEMBL28559658 | 0.79 | KDM4E (0.34) | HTTLMNAKDM4EALDH1A1CYP1A2 | |
| SCHEMBL18209664 | 0.76 | POLB (0.37) | — | |
| SCHEMBL20774866 | 0.75 | P2RX7 (0.31) | — | |
| SCHEMBL2595337 | 0.72 | — | — | |
| SCHEMBL18209671 | 0.71 | ALOX5 (0.33) | ALDH1A1 | |
| SCHEMBL1831743 | 0.69 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL28405286 | 0.68 | NNMT (0.37) | LMNATDP1KDM4EALDH1A1 | |
| SCHEMBL29153863 | 0.68 | MEN1 (0.37) | HTTLMNACYP1A2CYP2C19 | |
| SCHEMBL6065962 | 0.67 | LPAR1 (0.36) | HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110072863-B | RIP1 kinase inhibitors and methods of use | 豪夫迈·罗氏有限公司 | 2022-08-30 | — | — | CN | disclosed |