Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.31 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.31 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.31 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.31 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.31 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.31 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.31 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23782624 | 0.99 | IDO1 (0.35) | IDO1MEN1KMT2ASMN1; SMN2SLC11A2 | |
| Hydrochloric Acid SCHEMBL5388643 | 0.98 | IDO1 (0.36) | IDO1MEN1KMT2ASMN1; SMN2SLC11A2 | |
| SCHEMBL25907574 | 0.87 | MEN1 (0.32) | MEN1KMT2ASMN1; SMN2MPO | |
| Bromide SCHEMBL5382276 | 0.86 | IDO1 (0.33) | IDO1SLC11A2CYP1A2CYP2C19CYP2D6 | |
| Bromide SCHEMBL5373790 | 0.86 | IDO1 (0.33) | IDO1SLC11A2CYP1A2CYP2C19CYP2D6 | |
| Bromide SCHEMBL5374112 | 0.86 | IDO1 (0.33) | IDO1MEN1KMT2ASMN1; SMN2SLC11A2 | |
| SCHEMBL28755298 | 0.84 | IDO1 (0.33) | IDO1MEN1KMT2ASMN1; SMN2SLC11A2 | |
| Bromide SCHEMBL5382542 | 0.84 | IDO1 (0.35) | IDO1MEN1KMT2ASMN1; SMN2SLC11A2 | |
| SCHEMBL24179946 | 0.83 | MEN1 (0.30) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL22939563 | 0.82 | MEN1 (0.39) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260022113-A1 | Process for the Preparation of Pyroxasulfone | ATTICUS LLC (US) | 2026-01-22 | — | — | US | disclosed |
| US-20250361225-A1 | A PROCESS FOR PREPARATION OF 3-[5-(DIFLUOROMETHOXY)-1- METHYL-3-(TRIFLUOROMETHYL)PYRAZOL-4- YLMETHYLSULFONYL]-4,5-DIHYDRO-5,5-DIMETHYL-1,2-OXAZOLE AND ITS INTERMEDIATES | UPL LTD (IN) | 2025-11-27 | — | — | US | disclosed |
| WO-2023194957-A1 | A PROCESS FOR PREPARATION OF 3-[5-(DIFLUOROMETHOXY)-1- METHYL-3-(TRIFLUOROMETHYL)PYRAZOL-4- YLMETHYLSULFONYL]-4,5-DIHYDRO-5,5-DIMETHYL-1,2-OXAZOLE AND ITS INTERMEDIATES | UPL LIMITED (IN) | 2023-10-12 | — | — | WO | disclosed |
| CN-114716379-A | Preparation method of topramezone intermediate | 绍兴贝斯美化工股份有限公司 | 2022-07-08 | — | — | CN | disclosed |
| EP-2227458-B1 | Chiral 2-(Benzylsulfinyl)-thiazol derivatives and 2-[(1H-pyrazol-4-ylmethyl)sulfinyl]-thiazol derivatives with S-configuration as herbicide plant growth regulators | BAYER IP GMBH (DE) | 2016-06-22 | — | — | EP | disclosed |
| EP-1541561-B1 | PYRAZOLE DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF | IHARA CHEMICAL IND CO (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8754234-B2 | Chiral 2-(benzylsulfinyl)thiazole derivatives and 2-[(1H-pyrazol-4-ylmethyl)sulfinyl]thiazole derivatives, processes for their preparation and their use as herbicides and plant growth regulators | BAYER CROPSCIENCE AG (DE) | 2014-06-17 | — | — | US | disclosed |
| US-20100285958-A1 | Chiral 2-(benzylsulfinyl)Thiazole derivatives and 2-[(1H-pyrazol-4-ylmethyl)sulfinyl]thiazole derivatives, processes for their preparation and their use as herbicides and plant growth regulators | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-11-11 | — | — | US | disclosed |
| EP-2227458-A2 | 2-(BENZYL- AND 1H-PYRAZOL-4-YLMETHYL)SULFINYL-THIAZOL-DERIVATIVES AS HERBICIDES AND PLANT GROWTH REGULATORS | Bayer CropScience AG (DE) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068170-A2 | 2-(BENZYL- AND 1H-PYRAZOL-4-YLMETHYL)SULFINYL THIAZOLE DERIVATIVES AS HERBICIDES AND PLANT GROWTH REGULATORS | BAYER CROPSCIENCE AG (DE) | 2009-06-04 | — | — | WO | disclosed |
| EP-2065374-A1 | 2-(benzyl- and 1H-pyrazol-4-ylmethyl)sulfinyl-thiazol-derivatives as herbicides and plant growth regulators | Bayer CropScience AG (DE) | 2009-06-03 | — | — | EP | disclosed |
| US-20070249844-A1 | Pyrazole derivatives and process for the production thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-10-25 | — | — | US | disclosed |
| US-7256298-B2 | Pyrazole derivatives and process for the production thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-08-14 | — | — | US | disclosed |
| US-20070015805-A1 | Process for preparing 3-arylmethylthio- and 3-heteroarylmethylthio-4,5-dihydroisoxazoline derivatives | BAYER CROPSCIENCE GMBH (DE) | 2007-01-18 | — | — | US | disclosed |
| US-20050215797-A1 | Pyrazole derivatives and process for the production thereof | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2005-09-29 | — | — | US | disclosed |
| EP-1541561-A1 | PYRAZOLE DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250361225-A1 | A PROCESS FOR PREPARATION OF 3-[5-(DIFLUOROMETHOXY)-1- METHYL-3-(TRIFLUOROMETHYL)PYRAZOL-4- YLMETHYLSULFONYL]-4,5-DIHYDRO-5,5-DIMETHYL-1,2-OXAZOLE AND ITS INTERMEDIATES | DHPS, DHODH, FIS1 | IDO1 596/4885MEN1 1388/4885KMT2A 437/4885 |
| US-20070249844-A1 | Pyrazole derivatives and process for the production thereof | CBR3, CYP4Z1, CYP4F3 | IDO1 232/4885MEN1 4541/4885KMT2A 4132/4885 |
| US-20260022113-A1 | Process for the Preparation of Pyroxasulfone | AGXT, SLC6A5, CA2 | IDO1 1504/4885MEN1 4292/4885KMT2A 2723/4885 |
| US-20100285958-A1 | Chiral 2-(benzylsulfinyl)Thiazole derivatives and 2-[(1H-pyrazol-4-ylmethyl)sulfinyl]thiazole derivatives, processes for their preparation and their use as herbicides and plant growth regulators | STS, SULT2A1, SLTM | IDO1 1220/4885MEN1 4644/4885KMT2A 2053/4885 |
| US-20070015805-A1 | Process for preparing 3-arylmethylthio- and 3-heteroarylmethylthio-4,5-dihydroisoxazoline derivatives | CYP3A7, KMO, CYP4X1 | IDO1 24/4885MEN1 1533/4885KMT2A 419/4885 |
| US-20050215797-A1 | Pyrazole derivatives and process for the production thereof | CBR3, CYP4Z1, CYP4F3 | IDO1 232/4885MEN1 4541/4885KMT2A 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.